Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type–specific methylation in enhancers
Volume: 114, Issue: 51, Pages: 13525 - 13530
Published: Dec 4, 2017
Abstract
DNA methylation at promoters is an important determinant of gene expression. Earlier studies suggested that the insulin gene promoter is uniquely unmethylated in insulin-expressing pancreatic β-cells, providing a classic example of this paradigm. Here we show that islet cells expressing insulin, glucagon, or somatostatin share a lack of methylation at the promoters of the insulin and glucagon genes. This is achieved by rapid demethylation of the...
Paper Details
Title
Islet cells share promoter hypomethylation independently of expression, but exhibit cell-type–specific methylation in enhancers
Published Date
Dec 4, 2017
Volume
114
Issue
51
Pages
13525 - 13530
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