Structural insights into the potency of SK channel positive modulators
Abstract
Small-conductance Ca 2+ -activated K + (SK) channels play essential roles in the regulation of cellular excitability and have been implicated in neurological and cardiovascular diseases through both animal model studies and human genetic association studies. Over the past two decades, positive modulators of SK channels such as NS309 and 1-EBIO have been developed. Our previous structural studies have identified the binding pocket of 1-EBIO and...
Paper Details
Title
Structural insights into the potency of SK channel positive modulators
Published Date
Dec 7, 2017
Journal
Volume
7
Issue
1
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