Cognitive profile and 18F-fluorodeoxyglucose PET study in LRRK2 -related Parkinson's disease

Introduction LRRK2 gene mutations underlie the most common mendelian form of Parkinson's Disease (PD), designated PARK8, that shows clinical features similar to those in idiopathic PD (IPD). We assessed the cognitive functions and the cerebral metabolism measured with 18F-fluorodeoxyglucose (FDG)-PET in PARK8 patients compared with IPD. Patients and methods We enrolled eight PARK8 patients and eight IPD patients, comparable for onset age, stage,...