RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin
Abstract
Upon fertilisation, the sperm pronucleus acquires the competence to replicate the genome through a cascade of events that link chromatin remodelling to nuclear envelope formation. The factors involved have been partially identified and are poorly characterised. Here, using Xenopus laevis egg extracts we show that RNAs are required for proper nuclear envelope assembly following sperm DNA decondensation. Although chromatin remodelling and...
Paper Details
Title
RNAs coordinate nuclear envelope assembly and DNA replication through ELYS recruitment to chromatin
Published Date
Dec 14, 2017
Journal
Volume
8
Issue
1
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