A low fat diet ameliorates pathology but retains beneficial effects associated with CPT1b knockout in skeletal muscle
Abstract
Inhibiting fatty acid oxidation is one approach to lowering glucose levels in diabetes. Skeletal muscle specific Carnitine Palmitoyltransferase 1b knockout mice (Cpt1bm-/-) comprise a model of impaired fat oxidation; and have decreased fat mass and enhanced glucose disposal and muscle oxidative capacity compared to controls. However, unfavorable effects occur relative to controls when Cpt1bm-/- mice are fed a 25% fat diet, including decreased...
Paper Details
Title
A low fat diet ameliorates pathology but retains beneficial effects associated with CPT1b knockout in skeletal muscle
Published Date
Dec 14, 2017
Journal
Volume
12
Issue
12
Pages
e0188850 - e0188850
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