Current knowledge on the nucleotide agonists for the P2Y2 receptor
Abstract
P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6, P2Y11, P2Y12, P2Y13, and P2Y14). P2Y2 receptors are widely expressed and play important roles in multiple functionalities. Diquafosol tetrasodium, known as INS365, which was the first P2Y2 receptor agonists that had been approved in April 2010 and launched in Japan by Santen...
Paper Details
Title
Current knowledge on the nucleotide agonists for the P2Y2 receptor
Published Date
Jan 1, 2018
Volume
26
Issue
2
Pages
366 - 375
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