Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
Abstract
Alzheimer's disease is a common and devastating disease characterized by aggregation of the amyloid-β peptide. However, we know relatively little about the underlying molecular mechanisms or how to treat patients with Alzheimer's disease. Here we provide bioinformatic and experimental evidence of a conserved mitochondrial stress response signature present in diseases involving amyloid-β proteotoxicity in human, mouse and Caenorhabditis elegans...
Paper Details
Title
Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity
Published Date
Dec 1, 2017
Journal
Volume
552
Issue
7684
Pages
187 - 193
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History