Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis (Review)

Numerous studies over the past two decades have focused on the epithelial‑to‑mesenchymal transition (EMT) and its role in the development of metastasis. Certain studies highlighted the importance of EMT in the dissemination of tumor cells and metastasis of epithelium‑derived carcinomas. Tumor metastasis is a multistep process during which tumor cells change their morphology, and start to migrate and invade distant sites. The present review...