Impact of loss of SOAT2 function on disease progression in the lysosomal acid lipase-deficient mouse
Abstract
Although only a small proportion of cholesterol in the body is esterified, in several diseases marked expansion of the esterified cholesterol (EC) pool occurs. These include Wolman disease (WD) and Cholesteryl Ester Storage Disease (CESD) which both result from mutations in LIPA, the gene that encodes lysosomal acid lipase (LAL). The respective contributions that our three cholesterol esterifying enzymes make to EC production, especially in...
Paper Details
Title
Impact of loss of SOAT2 function on disease progression in the lysosomal acid lipase-deficient mouse
Published Date
Feb 1, 2018
Journal
Volume
130
Pages
7 - 14
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