LC–MS/MS screening strategy for cannabinoids, opiates, amphetamines, cocaine, benzodiazepines and methadone in human serum, urine and post-mortem blood as an effective alternative to immunoassay based methods applied in forensic toxicology for preliminary examination

An LC–MS/MS based screening method for cannabinoids, opiates, amphetamines, cocaine, benzodiazepines and methadone was developed for the analysis of human serum, urine and post-mortem blood and discussed as an effective alternative to immunoassay based screening methods. Two mass spectrometric systems with differences in sensitivity common known were used for method validation. A simple protein precipitation was applied for a sample volume of...