Altered expression of telomere‐associated genes in leukocytes among BRCA1 and BRCA2 carriers
Abstract
Telomere dysfunction resulting from telomere shortening and deregulation of shelterin components has been linked to the pathogenesis of age-related disorders, including cancer. Recent evidence suggests that BRCA1/2 (BRCA1 and BRCA2) tumor suppressor gene products play an important role in telomere maintenance. Although telomere shortening has been reported in BRCA1/2 carriers, the direct effects of BRCA1/2 haploinsufficiency on telomere...
Paper Details
Title
Altered expression of telomere‐associated genes in leukocytes among BRCA1 and BRCA2 carriers
Published Date
Jan 5, 2018
Journal
Volume
57
Issue
4
Pages
567 - 575
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