Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF high neutrophils
Abstract
Bone marrow-derived myeloid cells can accumulate within tumors and foster cancer outgrowth. Local immune-neoplastic interactions have been intensively investigated, but the contribution of the systemic host environment to tumor growth remains poorly understood. Here, we show in mice and cancer patients (n = 70) that lung adenocarcinomas increase bone stromal activity in the absence of bone metastasis. Animal studies reveal that the...
Paper Details
Title
Osteoblasts remotely supply lung tumors with cancer-promoting SiglecF high neutrophils
Published Date
Dec 1, 2017
Journal
Volume
358
Issue
6367
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