CK2 modulates adipocyte insulin-signaling and is up-regulated in human obesity
Abstract
Insulin plays a major role in glucose metabolism and insulin-signaling defects are present in obesity and diabetes. CK2 is a pleiotropic protein kinase implicated in fundamental cellular pathways and abnormally elevated in tumors. Here we report that in human and murine adipocytes CK2-inhibition decreases the insulin-induced glucose-uptake by counteracting Akt-signaling and GLUT4-translocation to the plasma membrane. In mice CK2 acts on...
Paper Details
Title
CK2 modulates adipocyte insulin-signaling and is up-regulated in human obesity
Published Date
Dec 14, 2017
Journal
Volume
7
Issue
1
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