Oxymatrine inhibits non–small cell lung cancer via suppression of EGFR signaling pathway

Epidermal growth factor receptor ( EGFR ) plays a crucial role in human non–small cell lung cancer ( NSCLC ) tumorigenesis. In this study, oxymatrine was identified as an EGFR signaling pathway inhibitor in NSCLC . Oxymatrine inhibited anchorage‐dependent and independent growth of NSCLC cell lines but had no cytotoxicity in normal lung cells. We found that exposure to oxymatrine not only suppressed the activity of wild‐type EGFR but also...