BMPR2 inhibits activin- and BMP-signaling via wild type ALK2
Abstract
TGF-β/BMP superfamily ligands require heteromeric complexes of type 1 and 2 receptors for ligand dependent downstream signaling. Activin A, a TGF-β superfamily member, inhibits growth of multiple myeloma cells, but the mechanism is unknown. We aimed to clarify how activins affect myeloma cell survival. Activin A activates the transcription factors SMAD2/3 through the ALK4 type 1 receptor, but may also activate SMAD1/5/8 through mutated variants...
Paper Details
Title
BMPR2 inhibits activin- and BMP-signaling via wild type ALK2
Published Date
Jan 1, 2018
Journal
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