Protective Effects of Garlic-Derived S-Allylmercaptocysteine on IL-1β-Stimulated Chondrocytes by Regulation of MMPs/TIMP-1 Ratio and Type II Collagen Expression via Suppression of NF-κB Pathway

Background. Garlic-derived S-allylmercaptocysteine (SAMC) has widely been used in many disease therapies. However, the potential effects and mechanism of SAMC on IL-1 β -stimulated chondrocytes are unclear. Methods . Chondrocytes were isolated, and 5 ng/mL of IL-1 β was added to mimic the in vitro osteoarthritis (OA) model. SAMC (20 and 60 μ M) was used for the treatment in OA model. Cell viability was assessed by MTT method. Western blotting,...