LARG GEF and ARHGAP18 orchestrate RhoA activity to control mesenchymal stem cell lineage
Abstract
The quantity and quality of bone depends on osteoblastic differentiation of mesenchymal stem cells (MSCs), where adipogenic commitment depletes the available pool for osteogenesis. Cell architecture influences lineage decisions, where interfering with cytoskeletal structure promotes adipogenesis. Mechanical strain suppresses MSC adipogenesis partially through RhoA driven enhancement of cytoskeletal structure. To understand the basis of...
Paper Details
Title
LARG GEF and ARHGAP18 orchestrate RhoA activity to control mesenchymal stem cell lineage
Published Date
Feb 1, 2018
Journal
Volume
107
Pages
172 - 180
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Notes
History