Cryptococcal Meningitis in a HIV-Negative Patient

Published on Dec 12, 2017in European Journal of Case Reports in Internal Medicine
· DOI :10.12890/2017_000778
Cátia Barreiros , Lúcia Meireles-Brandão1
Estimated H-index: 1
+ 2 AuthorsDiana Guerra
Abstract
Sarcoidosis is a risk factor for the development of cryptococcal infection due to dysfunction at T-cell level. Its rarity may, however, delay diagnosis and treatment. We describe the case of a 60-year-old man, diagnosed with sarcoidosis since 1999. He had never received systemic immunomodulatory therapy, such as corticosteroid therapy. In 2012, he was diagnosed with pulmonary cryptococcosis and treated with fluconazole. In April 2013, he presented with symptoms compatible with central nervous system (CNS) infection, namely, Cryptococcus neoformans meningitis. He was treated with amphotericin B, followed by fluconazole. The clinical outcome was favourable.
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