Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT /mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation
Abstract
Head and neck squamous cell carcinoma ( HNSCC ) clearly involves activation of the Akt mammalian target of rapamycin ( mTOR ) signalling pathway. However, the effectiveness of treatment with the mTOR inhibitor rapamycin is often limited by chemoresistance. Melatonin suppresses neoplastic growth via different mechanisms in a variety of tumours. In this study, we aimed to elucidate the effects of melatonin on rapamycin‐induced HNSCC cell death and...
Paper Details
Title
Combination of melatonin and rapamycin for head and neck cancer therapy: Suppression of AKT /mTOR pathway activation, and activation of mitophagy and apoptosis via mitochondrial function regulation
Published Date
Jan 9, 2018
Journal
Volume
64
Issue
3
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