Domestication of self-splicing introns during eukaryogenesis: the rise of the complex spliceosomal machinery
Abstract
The spliceosome is a eukaryote-specific complex that is essential for the removal of introns from pre-mRNA. It consists of five small nuclear RNAs (snRNAs) and over a hundred proteins, making it one of the most complex molecular machineries. Most of this complexity has emerged during eukaryogenesis, a period that is characterised by a drastic increase in cellular and genomic complexity. Although not fully resolved, recent findings have started...
Paper Details
Title
Domestication of self-splicing introns during eukaryogenesis: the rise of the complex spliceosomal machinery
Published Date
Dec 1, 2017
Journal
Volume
12
Issue
1
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