Region‐specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice
Abstract
Glial glutamate transporter GLT1 plays a key role in the maintenance of extracellular glutamate homeostasis. Recent human genetic studies have suggested that de novo mutations in GLT1 (EAAT2) cause early-onset epilepsy with multiple seizure types. Consistent with these findings, global GLT1 null mice show lethal spontaneous seizures. The consequences of GLT1 dysfunction vary between different brain regions, suggesting that the role of GLT1...
Paper Details
Title
Region‐specific deletions of the glutamate transporter GLT1 differentially affect seizure activity and neurodegeneration in mice
Published Date
Dec 6, 2017
Journal
Volume
66
Issue
4
Pages
777 - 788
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