Template-based quaternary structure prediction of proteins using enhanced profile-profile alignments

Proteins often exist as their multimeric forms when they function as so‐called biological assemblies consisting of the specific number and arrangement of protein subunits. Consequently, elucidating biological assemblies is necessary to improve understanding of protein function. Template‐Based Modeling (TBM), based on known protein structures, has been used widely for protein structure prediction. Actually, TBM has become an increasingly useful...