Enhancing the precision of genetic lineage tracing using dual recombinases
Abstract
The Cre-loxP recombination system is the most widely used technology for in vivo tracing of stem or progenitor cell lineages. The precision of this genetic system largely depends on the specificity of Cre recombinase expression in targeted stem or progenitor cells. However, Cre expression in nontargeted cell types can complicate the interpretation of lineage-tracing studies and has caused controversy in many previous studies. Here we describe a...
Paper Details
Title
Enhancing the precision of genetic lineage tracing using dual recombinases
Published Date
Nov 13, 2017
Journal
Volume
23
Issue
12
Pages
1488 - 1498
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