Arginine reverses growth hormone resistance through the inhibition of toll-like receptor 4-mediated inflammatory pathway

Objective Growth hormone stimulates growth by increasing insulin-like growth factor 1 expression and secretion. In the presence of insufficient nutrients, GH increases, whereas IGF-1 expression becomes severely suppressed, leading to GH resistance. This study aimed to explore the effect of arginine (Arg) on GH resistance during malnutrition and to describe its underlying mechanism. Methods C57BL/6 J mice were injected intraperitoneally with Arg...