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Chapter 1 – Reproducibility in Biomedical Research

Published on Jan 1, 2018
· DOI :10.1016/B978-0-12-804725-5.00001-X
Kevin Mullane12
Estimated H-index: 12
,
Michael J. Curtis27
Estimated H-index: 27
,
Michael Williams17
Estimated H-index: 17
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Abstract
Abstract The biomedical research ecosystem—academic, federal, and industrial—is dedicated to understanding human disease causality and developing effective therapeutics. The successes of this system over the past century have resulted in many effective drugs leading society to expect an endless supply of new therapeutics, particularly for chronic diseases that lack effective treatments (e.g., Alzheimer’s, diabetes). An increased recognition that the quality, relevance, reliability, and reproducibility of biomedical research cannot be guaranteed despite self-correction and peer review, coupled with the incessant hyping of inconsequential data by authors and their institutions, has led to a situation that is incompatible with sustained success in drug discovery. This risks the loss of credibility with the public, which does not bode well for the future of biomedical research. This chapter outlines the reproducibility problem and its magnitude, setting the stage for potential solutions that are discussed elsewhere in this monograph.
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References274
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#1Mark Lucanic (Buck Institute for Research on Aging)H-Index: 6
#2W. Todd Plummer (Buck Institute for Research on Aging)H-Index: 2
Last.Erik Johnson (UO: University of Oregon)H-Index: 2
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#1Daniel J. Holder (USMA: United States Military Academy)H-Index: 26
#2Michael J. Marino (USMA: United States Military Academy)H-Index: 27
#1C.X. Weichenberger (AmeriCorps VISTA)H-Index: 2
#2Edwin Pozharskiy (UMB: University of Maryland, Baltimore)H-Index: 16
Last.Bernhard Rupp (AmeriCorps VISTA)H-Index: 30
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#1Brian A. Nosek (UVA: University of Virginia)H-Index: 60
#2Timothy M. Errington (Center for Open Science)H-Index: 8
View next paperChapter 6 – Biomedical Research in the 21st Century: Multiple Challenges in Resolving Reproducibility Issues