Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy
Abstract
Subunit vaccines have been investigated in over 1000 clinical trials of cancer immunotherapy, but have shown limited efficacy. Nanovaccines may improve efficacy but have rarely been clinically translated. By conjugating molecular vaccines with Evans blue (EB) into albumin-binding vaccines (AlbiVax), here we develop clinically promising albumin/AlbiVax nanocomplexes that self-assemble in vivo from AlbiVax and endogenous albumin for efficient...
Paper Details
Title
Albumin/vaccine nanocomplexes that assemble in vivo for combination cancer immunotherapy
Published Date
Dec 5, 2017
Journal
Volume
8
Issue
1
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