Low immunogenic bio-nanocapsule based on hepatitis B virus escape mutants

Volume: 14, Issue: 2, Pages: 595 - 600
Published: Feb 1, 2018
Abstract
Bio-nanocapsules (BNCs) consisting of hepatitis B virus surface antigen (HBsAg) L proteins and phospholipids are used as efficient non-viral carriers for liver-specific delivery of genes and drugs. Considering the administration to HB vaccinees and HB patients, endogenous anti-HBsAg immunoglobulins (HBIGs) may reduce the delivery efficacy and prevent repetitive administration. Therefore, low immunogenic BNCs were generated by inserting two point...
Paper Details
Title
Low immunogenic bio-nanocapsule based on hepatitis B virus escape mutants
Published Date
Feb 1, 2018
Volume
14
Issue
2
Pages
595 - 600
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