Investigation of the effect of blood hematocrit and lipid content on the blood volume deposited by a disposable dried blood spot collection device

When using dried blood spot (DBS) sampling for the quantitative bioanalysis of circulating concentrations of drugs, metabolites and endogenous analytes, it is important that a fixed volume of blood is deposited to overcome the issues associated with blood hematocrit (HCT) and homogeneity. The volumetric performance of the KTH DBS collection device was tested with radiolabelled [14C]-diclofenac. It was demonstrated that the device deposits a...