8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis
Abstract
Mitochondrial DNA (mtDNA) resides in close proximity to metabolic reactions, and is maintained by the 8-oxoguanine DNA glycosylase (Ogg1) and other members of the base excision repair pathway. Here, we tested the hypothesis that changes in liver metabolism as under fasting/feeding conditions would be sensed by liver mtDNA, and that Ogg1 deficient mice might unravel a metabolic phenotype. Wild type (WT) and ogg1−/− mice were either fed ad libitum...
Paper Details
Title
8-oxoguanine DNA glycosylase (Ogg1) controls hepatic gluconeogenesis
Published Date
Jan 1, 2018
Journal
Volume
61
Pages
56 - 62
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