Metabolites Associated With Risk of Developing Mobility Disability in the Health, Aging and Body Composition Study

Metabolic pathways that give rise to functional decline and mobility disability in older adults are incompletely understood. To identify metabolic perturbations that may affect functional decline, nontargeted metabolomics was used to measure 350 metabolites in baseline plasma from 313 black men in the Health ABC Study (median age 74 years). Usual gait speed was measured over 20 m. Cross-sectional relationships between gait speed and metabolites...