A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors
Abstract
As of mid-2017, only one structure of the human immunodeficiency virus (HIV) integrase core domain co-crystallised with an active site inhibitor was reported. In this structure (1QS4), integrase is complexed with a diketo-acid based strand-transfer inhibitor (INSTI). This structure has been a preferred platform for the structure-based design of INSTIs despite concerns relating to structural irregularities arising from crystallographic packing...
Paper Details
Title
A structure-based design approach to advance the allyltyrosine-based series of HIV integrase inhibitors
Published Date
Mar 1, 2018
Journal
Volume
74
Issue
12
Pages
1253 - 1268
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