Original paper
Highly sensitive determination of alendronate in human plasma and dialysate using metal-free HPLC-MS/MS
Abstract
A highly sensitive method was developed for the analysis of alendronate in human plasma and dialysate using MonoSpin™ SAX® extraction and metal-free high-performance liquid chromatography (HPLC)-tandem mass spectrometry (MS/MS) following methylation with trimethylsilyldiazomethane. The chromatographic separation of the derivatives for alendronate and alendronate-d6 was achieved on an L-column2 ODS metal-free column (50 mm × 2 mm i.d., particle...
Paper Details
Title
Highly sensitive determination of alendronate in human plasma and dialysate using metal-free HPLC-MS/MS
Published Date
Jan 1, 2018
Journal
Volume
30
Pages
14 - 20
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Notes
History