Type‐1 astrocyte‐like stem cells harboring Cacna1d gene deletion exhibit reduced proliferation and decreased neuronal fate choice
Abstract
In the central nervous system, CaV 1.2 and CaV 1. 3 constitute the main L-type voltage-gated calcium channels (LTCCs) coupling membrane depolarization to gene transcription. We have previously demonstrated that inducible disruption of Cav1.2 in type-1 astrocyte-like stem cells of the adult dentate gyrus (DG) impairs hippocampal neurogenesis in a cell-autonomous fashion. To address the role of Cav1.3 channels (encoded by the Cacna1d gene), we...
Paper Details
Title
Type‐1 astrocyte‐like stem cells harboring Cacna1d gene deletion exhibit reduced proliferation and decreased neuronal fate choice
Published Date
Nov 22, 2017
Journal
Volume
28
Issue
2
Pages
97 - 107
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