Match!

Prostate-specific antigen (PSA) testing of men in UK general practice: a 10-year longitudinal cohort study

Published on Oct 30, 2017in BMJ Open2.38
· DOI :10.1136/bmjopen-2017-017729
Grace J. Young5
Estimated H-index: 5
(UoB: University of Bristol),
Sean Harrison8
Estimated H-index: 8
(UoB: University of Bristol)
+ 10 AuthorsChris Metcalfe43
Estimated H-index: 43
(UoB: University of Bristol)
Abstract
Objectives Cross-sectional studies suggest that around 6% of men undergo prostate-specific antigen (PSA) testing each year in UK general practice (GP). This longitudinal study aims to determine the cumulative testing pattern of men over a 10-year period and whether this testing can be considered equivalent to screening for prostate cancer (PCa). Setting, participants and outcome measures Patient-level data on PSA tests, biopsies and PCa diagnoses were obtained from the UK Clinical Practice Research Datalink (CPRD) for the years 2002 to 2011. The cumulative risks of PSA testing and of being diagnosed with PCa were estimated for the 10-year study period. Associations of a man’s age, region and index of multiple deprivation with the cumulative risk of PSA testing and PCa diagnosis were investigated. Rates of biopsy and diagnosis, following a high test result, were compared with those from the programme of PSA testing in the Prostate Testing for Cancer and Treatment (ProtecT) study. Results The 10-year risk of exposure to at least one PSA test in men aged 45 to 69 years in UK GP was 39.2% (95% CI 39.0 to 39.4%). The age-specific risks ranged from 25.2% for men aged 45–49 years to 53.0% for men aged 65–69 years (p for trend Conclusion A high proportion of men aged 45–69 years undergo PSA tests in UK GP: 39% over a 10-year period. A high proportion of these tests appear to be for the investigation of lower urinary tract symptoms and not screening for PCa. Trial registration number ISRCTN20141297,NCT02044172.
  • References (25)
  • Citations (8)
References25
Newest
#1Jenny L DonovanH-Index: 82
#2Freddie C. HamdyH-Index: 71
Last.David E. Neal (University of Cambridge)H-Index: 90
view all 38 authors...
347 CitationsSource
#1Paul Nderitu (Guy's Hospital)H-Index: 4
#2Mieke Van Hemelrijck ('KCL': King's College London)H-Index: 27
Last.Simon Chowdhury (Guy's Hospital)H-Index: 27
view all 7 authors...
5 CitationsSource
#1Sue Moss (QMUL: Queen Mary University of London)H-Index: 54
#2J. Melia (University of Cambridge)H-Index: 2
Last.Mike Kirby (University of Hertfordshire)H-Index: 25
view all 5 authors...
12 CitationsSource
#1Emily Herrett (Lond: University of London)H-Index: 16
#2Arlene M. Gallagher (UU: Utrecht University)H-Index: 13
Last.Tjeerd van Staa (University of Manchester)H-Index: 83
view all 7 authors...
697 CitationsSource
#1Kristen Pickles (Centre for Values, Ethics and the Law in Medicine)H-Index: 8
#2Stacy M Carter (Centre for Values, Ethics and the Law in Medicine)H-Index: 26
Last.Lucie Rychetnik (Centre for Values, Ethics and the Law in Medicine)H-Index: 19
view all 3 authors...
16 CitationsSource
#1Fritz H. Schröder (Erasmus University Medical Center)H-Index: 89
#2Jonas Hugosson (University of Gothenburg)H-Index: 50
Last.Anssi Auvinen (RMIT: RMIT University)H-Index: 73
view all 29 authors...
656 CitationsSource
#1J. Athene Lane (UoB: University of Bristol)H-Index: 32
#2Jenny L Donovan (UoB: University of Bristol)H-Index: 82
Last.Freddie C. Hamdy (University of Oxford)H-Index: 71
view all 13 authors...
144 CitationsSource
#1E.H.J. HamoenH-Index: 6
#2D.F.M. Reukers (Radboud University Nijmegen Medical Centre)H-Index: 1
Last.Maroeska M. Rovers (Radboud University Nijmegen Medical Centre)H-Index: 52
view all 6 authors...
13 CitationsSource
#1Monique J. Roobol (EUR: Erasmus University Rotterdam)H-Index: 61
6 CitationsSource
#1Tobias Nordström (KI: Karolinska Institutet)H-Index: 12
#2Markus Aly (KI: Karolinska Institutet)H-Index: 18
Last.Henrik Grönberg (KI: Karolinska Institutet)H-Index: 72
view all 6 authors...
62 CitationsSource
Cited By8
Newest
#1Jessica Watson (UoB: University of Bristol)H-Index: 8
#2Luke T. A. Mounce (University of Exeter)H-Index: 7
Last.Willie Hamilton (University of Exeter)H-Index: 59
view all 5 authors...
Source
#1Tommy Nyberg (University of Cambridge)H-Index: 26
#2Debra Frost (University of Cambridge)H-Index: 30
Last.Antonis C. Antoniou (University of Cambridge)H-Index: 60
view all 32 authors...
Source
#1Richard O. Williams (University of Manchester)H-Index: 51
#2Benjamin Brown (University of Manchester)H-Index: 10
Last.Niels Peek (University of Manchester)H-Index: 27
view all 5 authors...
Source
Source
#1Kari A.O. Tikkinen (UH: University of Helsinki)H-Index: 23
#2Philipp Dahm (UMN: University of Minnesota)H-Index: 41
Last.Thomas Agoritsas (McMaster University)H-Index: 28
view all 19 authors...
8 CitationsSource
#1Robin W.M. VernooijH-Index: 12
#2Lyubov Lytvyn (McMaster University)H-Index: 15
Last.Thomas AgoritsasH-Index: 28
view all 7 authors...
4 CitationsSource
#1Joshua J. Fenton (UC Davis: University of California, Davis)H-Index: 26
#2Meghan S Weyrich (UC Davis: University of California, Davis)H-Index: 5
Last.Joy Melnikow (UC Davis: University of California, Davis)H-Index: 26
view all 6 authors...
50 CitationsSource
#1Richard M. Martin (UoB: University of Bristol)H-Index: 102
#2Jenny L Donovan (NIHR: National Institute for Health Research)H-Index: 82
Last.Freddie C. Hamdy (University of Oxford)H-Index: 71
view all 26 authors...
63 CitationsSource