Clinical studies in CRS and HIPEC: Trials, tribulations, and future directions-A systematic review

Background The field of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) has suffered from a lack of clinical trials to validate its expanding use. Objective To evaluate published and ongoing clinical trials seeking to better define role of CRS/HIPEC in the treatment of peritoneal surface malignancies. Methods Systematic review by PubMed search was performed using terms “Clinical trial,” “intraperitoneal...