NIMG-74. RADIOMICS OF TUMOR INVASION 2.0: COMBINING MECHANISTIC TUMOR INVASION MODELS WITH MACHINE LEARNING MODELS TO ACCURATELY PREDICT TUMOR INVASION IN HUMAN GLIOBLASTOMA PATIENTS

In glioblastoma (GBM), contrast enhanced (CE)-MRI delineates bulk tumor with contrast-enhancement but poorly characterizes invasive tumor in the nonenhancing T2W abnormality. There is extensive literature in both machine-learning (ML) and mechanistic mathematical oncology seeking to accurately predict diffuse tumor invasion from multi-parametric MRI. ML offers strengths of a data-driven iterative approach, while mechanistic...