Icons / Logo / Facebook Created with Sketch. Icons / Logo / Google Created with Sketch. Icons / Logo / ORCID Created with Sketch. Branding/Logomark minus Citation Combined Shape Icon/Bookmark-empty Icon/Copy Icon/Collection Icon/Close Copy 7 no author result Created with Sketch. Icon/Back Created with Sketch. Match!

Longitudinal effects of cognitive behavioral therapy for depression on the neural correlates of emotion regulation

Published on Jan 1, 2018in Psychiatry Research-neuroimaging 2.21
· DOI :10.1016/j.pscychresns.2017.11.002
Harry Rubin-Falcone4
Estimated H-index: 4
(Columbia University),
Jochen Weber23
Estimated H-index: 23
(Columbia University)
+ 7 AuthorsJeffrey M. Miller13
Estimated H-index: 13
(Columbia University)
Cite
Abstract
Abstract Cognitive behavioral therapy (CBT) is effective for a substantial minority of patients suffering from major depressive disorder (MDD), but its mechanism of action at the neural level is not known. As core techniques of CBT seek to enhance emotion regulation, we scanned 31 MDD participants prior to 14 sessions of CBT using functional magnetic resonance imaging (fMRI) and a task in which participants engaged in a voluntary emotion regulation strategy while recalling negative autobiographical memories. Eighteen healthy controls were also scanned. Twenty-three MDD participants completed post-treatment fMRI scanning, and 12 healthy volunteers completed repeat scanning without intervention. Better treatment outcome was associated with longitudinal enhancement of the emotion regulation-dependent BOLD contrast within subgenual anterior cingulate, medial prefrontal cortex, and lingual gyrus. Baseline emotion regulation-dependent BOLD contrast did not predict treatment outcome or differ between MDD and control groups. CBT response may be mediated by enhanced downregulation of neural activity during emotion regulation; brain regions identified overlap with those found using a similar task in a normative sample, and include regions related to self-referential and emotion processing. Future studies should seek to determine specificity of this downregulation to CBT, and evaluate it as a treatment target in MDD.
  • References (59)
  • Citations (7)
Cite
References59
Newest
Published on Mar 1, 2017in Brain Stimulation 6.92
Martin J. Herrmann41
Estimated H-index: 41
(University of Würzburg),
Andrea Katzorke3
Estimated H-index: 3
(University of Würzburg)
+ 4 AuthorsJürgen Deckert31
Estimated H-index: 31
(University of Würzburg)
Abstract Background Animal as well as human research indicated that the ventral medial prefrontal cortex (vmPFC) is highly relevant for fear extinction learning. Recently, we showed that targeting the vmPFC with high-frequency repetitive transcranial magnetic stimulation (rTMS) in a placebo-controlled study with 45 healthy controls induced higher prefrontal activity during extinction of conditioned stimuli (CS+) in the active compared to the sham stimulated group and better extinction learning a...
Published on Jan 24, 2017in bioRxiv
Tor D. Wager67
Estimated H-index: 67
(CU: University of Colorado Boulder),
Lisa Feldman Barrett L F132
Estimated H-index: 132
(NU: Northeastern University)
The insula plays a key role in a wide range of brain processes, from viscerosensation and pain to motivation, emotion, and cognitive control. While human neuroimaging studies in all these domains report activations in the insula, little systematic attention is paid to anatomical subdivisions that may provide the basis for functional sub-regions. We conducted a meta-analysis of insular tasks across studies in four domains: emotion, pain, attention switching, and working memory. Using a priori sub...
Published on Nov 1, 2016in Psychological Science 4.90
Ajay B. Satpute18
Estimated H-index: 18
(Pomona College),
Erik C. Nook5
Estimated H-index: 5
(Harvard University)
+ 3 AuthorsKevin N. Ochsner68
Estimated H-index: 68
(Columbia University)
The demands of social life often require categorically judging whether someone’s continuously varying facial movements express “calm” or “fear,” or whether one’s fluctuating internal states mean one feels “good” or “bad.” In two studies, we asked whether this kind of categorical, “black and white,” thinking can shape the perception and neural representation of emotion. Using psychometric and neuroimaging methods, we found that (a) across participants, judging emotions using a categorical, “black...
Anders Eklund13
Estimated H-index: 13
(Linköping University),
Thomas E. Nichols69
Estimated H-index: 69
(Warw.: University of Warwick),
Hans Knutsson32
Estimated H-index: 32
(Linköping University)
The most widely used task functional magnetic resonance imaging (fMRI) analyses use parametric statistical methods that depend on a variety of assumptions. In this work, we use real resting-state data and a total of 3 million random task group analyses to compute empirical familywise error rates for the fMRI software packages SPM, FSL, and AFNI, as well as a nonparametric permutation method. For a nominal familywise error rate of 5%, the parametric statistical methods are shown to be conservativ...
Published on Jul 1, 2016in Journal of Affective Disorders 4.08
Lisa Hopfinger2
Estimated H-index: 2
,
Matthias Berking35
Estimated H-index: 35
+ 1 AuthorsDavid Daniel Ebert30
Estimated H-index: 30
Background Childhood trauma increases the risks of both depression and dysfunctional emotion regulation, which is a factor that has been strongly linked to depression. Because of these demonstrated relationships, it can be hypothesized that dysfunctional emotion regulation is a mediator of the association between childhood trauma and depression. Methods To test this hypothesis, we assessed the indirect effect of emotion regulation (Emotion Regulation Skills Questionnaire) on the relationship bet...
Published on Apr 1, 2016in Acta Neuropsychiatrica 1.98
George Franklin1
Estimated H-index: 1
(Royal Edinburgh Hospital),
Alan Carson27
Estimated H-index: 27
(Royal Edinburgh Hospital),
Killian A. Welch10
Estimated H-index: 10
(Royal Edinburgh Hospital)
Although cognitive behavioural therapy (CBT) has been shown to be an effective treatment for depression, the biological mechanisms underpinning it are less clear. This review examines if it is associated with changes identifiable with current brain imaging technologies.To better understand the mechanisms by which CBT exerts its effects, we undertook a systematic review of studies examining brain imaging changes associated with CBT treatment of depression.Ten studies were identified, five applyin...
Published on Jan 1, 2016in Journal of Affective Disorders 4.08
Jie-Yu Chuang2
Estimated H-index: 2
(University of Cambridge),
Kirstie J. Whitaker12
Estimated H-index: 12
(University of Cambridge)
+ 14 AuthorsAdrienne O. van Nieuwenhuizen4
Estimated H-index: 4
(University of Cambridge)
The study was funded by the Medial Research Council (grant: G0802226). The IMPACT clinical trial was funded by the NHS Health Technology Assessment (HTA) Programme, Central Manchester and Manchester Children's University Hospitals NHS Trust, and the Cambridge and Peterborough Mental Health Trust. Additional support was provided by the jointly funded Medical Research Council/Wellcome Trust Behavioural and Clinical Neuroscience Institute, University of Cambridge, and the National Institute for Hea...
Published on Nov 1, 2015in Psychological Medicine 5.64
Colleen Stiles-Shields12
Estimated H-index: 12
(NU: Northwestern University),
Marya E. Corden7
Estimated H-index: 7
(NU: Northwestern University)
+ 2 AuthorsDavid C. Mohr64
Estimated H-index: 64
(NU: Northwestern University)
Abstract Cognitive behavioral therapy (CBT) can be delivered efficaciously through various modalities, including telephone (T-CBT) and face-to-face (FtF-CBT). The purpose of this study was to explore predictors of outcome in T-CBT and FtF-CBT for depression. A total of 325 depressed participants were randomized to receive eighteen 45-min sessions of T-CBT or FtF-CBT. Depression severity was measured using the Hamilton Depression Rating Scale (HAMD) and the Patient Health Questionnaire-9 (PHQ-9)....
Published on Sep 1, 2015in Journal of Affective Disorders 4.08
Joana Straub6
Estimated H-index: 6
,
Paul L. Plener21
Estimated H-index: 21
+ 4 AuthorsBirgit Abler26
Estimated H-index: 26
Abstract Background While major effort has been put in investigating neural correlates of depression and its treatment in adults, less is known about the effects of psychotherapy in adolescents. Given the concordance of the ventral striatum, amygdala, hippocampus and the subgenual anterior cingulate cortex (sgACC) as correlates of depression and their involvement in reward processing, we used functional magnetic resonance imaging (fMRI) during performance of a monetary reward task in an interven...
Published on Mar 30, 2015in Journal of Medical Internet Research 4.95
Robert R. Morris10
Estimated H-index: 10
(MIT: Massachusetts Institute of Technology),
Stephen Matthew Schueller25
Estimated H-index: 25
,
Rosalind W. Picard77
Estimated H-index: 77
(MIT: Massachusetts Institute of Technology)
Background: Self-guided, Web-based interventions for depression show promising results but suffer from high attrition and low user engagement. Online peer support networks can be highly engaging, but they show mixed results and lack evidence-based content. Objective: Our aim was to introduce and evaluate a novel Web-based, peer-to-peer cognitive reappraisal platform designed to promote evidence-based techniques, with the hypotheses that (1) repeated use of the platform increases reappraisal and ...
Cited By7
Newest
Published in Current Psychiatry Reports 3.82
Katharine Dunlop (Cornell University), Aleksandr Talishinsky (Cornell University), Conor Liston21
Estimated H-index: 21
(Cornell University)
Purpose of Review Poor treatment response is a hallmark of major depressive disorder. To tackle this problem, recent neuroimaging studies have sought to characterize antidepressant response in terms of pretreatment differences in intrinsic functional brain networks. Our aim is to review recent studies that predict antidepressant response using intrinsic network connectivity. We discuss current methodological limitations and directions for future antidepressant biomarker studies.
Published on Mar 26, 2019in Clinical psychological science
Sanne J. E. Bruijniks1
Estimated H-index: 1
(PHRI: Public Health Research Institute),
Robert J. DeRubeis49
Estimated H-index: 49
(UPenn: University of Pennsylvania)
+ 1 AuthorsMarcus J.H. Huibers32
Estimated H-index: 32
(UPenn: University of Pennsylvania)
Insight into how cognitive behavioral therapy (CBT) works is urgently needed to improve depressive outcome. First, we discuss the role of learning in CBT for depression by reviewing evidence for le...
Published on Feb 11, 2019in Psychological Medicine 5.64
Harry Rubin-Falcone4
Estimated H-index: 4
,
Jochen Weber23
Estimated H-index: 23
+ 8 AuthorsJ. John Mann108
Estimated H-index: 108
Published on Jan 1, 2019
Je-Yeon Yun8
Estimated H-index: 8
(SNU: Seoul National University),
Seung-Hwan Lee21
Estimated H-index: 21
(Inje University)
Earlier identification of psychiatric patients who are prone to treatment resistance could avoid the frustration of a trial-and-error approach and might facilitate the design of more optimized treatment regimens and setting of individualized level of care. Although current candidate biomarkers for psychiatric disorders await further validation, knowledge on candidate genomic and brain-based biomarkers is increasing rapidly. Thus, this chapter illustrates recent study findings regarding clinical ...
Published on Jan 1, 2019in Psychiatry Research-neuroimaging 2.21
Wenwei Ren5
Estimated H-index: 5
(First Affiliated Hospital of Wenzhou Medical University),
Huihua Qiu2
Estimated H-index: 2
(First Affiliated Hospital of Wenzhou Medical University)
+ 21 AuthorsChangjin Li1
Estimated H-index: 1
(WMU: Wenzhou Medical College)
ABSTRACT Depressive and anxiety symptoms are frequently observed in breast cancer survivors. To date, few randomized controlled trials have been conducted on the efficacy of cognitive behavioural therapy (CBT) for depressive and anxiety symptoms in Chinese population. This study aims to verify the efficacy of CBT in Chinese breast cancer survivors. Women ( n = 392) with breast cancer were randomly assigned to 3 groups: CBT ( n = 98), self-care management (SCM, n = 98), and usual care (UC, n = 19...
Published on Nov 1, 2018
J. Siva Ramakrishna2
Estimated H-index: 2
,
Hariharan Ramasangu1
Estimated H-index: 1
Functional interactions among the brain regions define a meaningful representation of human brain activity. Estimation of time-varying interactions using functional MRI (fMRI) becomes challenging due to the complex brain signal dynamics. The evaluation and identification of these dynamical interactions between brain regions is an important component of the brain study. This paper considers Bayesian switching and empirical mode decomposition techniques for identifying connectivity strengths in a ...
Published on Sep 1, 2018in Psychiatry Research-neuroimaging 2.21
Anjali Sankar4
Estimated H-index: 4
(Yale University),
Alice Melin1
Estimated H-index: 1
(UEL: University of East London)
+ 3 AuthorsCynthia H.Y. Fu41
Estimated H-index: 41
(UEL: University of East London)
Longitudinal neuroimaging studies in major depression have revealed cortico-limbic abnormalities which are modulated by treatment. We performed a systematic review and metaanalysis of psychotherapy treatment studies measuring neural function and metabolism using fMRI, PET, SPECT and MRS. Seventeen studies were included in the systematic review, total of 200 major depression participants (mean age 37.6 years), all medication free, and 116 healthy controls (mean age 36.4 years). Neuroimaging asses...
Published on Sep 1, 2018
J. Siva Ramakrishna2
Estimated H-index: 2
,
Hariharan Ramasangu1
Estimated H-index: 1
This paper considers a graphical framework for identifying connectivity strengths in cognitive dataset. Functional MRI (fMRI) data with two cognitive states used for the analysis. In general fMRI data expressed in terms of number of voxels and Region of Interests (ROI). Task specific brain activation detection using fMRI is a challenging activity. The connectivity analysis among the ROIs gives inference about connectivity strengths among ROIs. In this paper it is identified through a graphical a...
Published on Aug 9, 2018in Brain Sciences
Moussa A. Chalah9
Estimated H-index: 9
,
Samar S. Ayache18
Estimated H-index: 18
Background: Major depressive disorder (MDD) stands among the most frequent psychiatric disorders. Cognitive behavioral therapy (CBT) has been shown to be effective for treating depression, yet its neural mechanisms of action are not well elucidated. The objective of this work is to assess the available neuroimaging studies exploring CBT’s effects in adult patients with MDD. Methods: Computerized databases were consulted till April 2018 and a research was conducted according to PRISMA guidelines ...
Antonie Rubart , Fritz Hohagen41
Estimated H-index: 41
,
Bartosz Zurowski12
Estimated H-index: 12
Die Depression – eine der haufigsten psychischen Erkrankungen in Deutschland. Dieser Beitrag vermittelt Grundwissen uber die Bildgebung in der Psychotherapieforschung und beschreibt Erklarungsmodelle fur neurobiologische Prozesse mit der Moglichkeit der Vorhersage des Therapieerfolgs mittels bildgebender Verfahren.