Statistical and integrative system-level analysis of DNA methylation data.
Abstract
Epigenetics plays a key role in cellular development and function. Alterations to the epigenome are thought to capture and mediate the effects of genetic and environmental risk factors on complex disease. Currently, DNA methylation is the only epigenetic mark that can be measured reliably and genome-wide in large numbers of samples. This Review discusses some of the key statistical challenges and algorithms associated with drawing inferences...
Paper Details
Title
Statistical and integrative system-level analysis of DNA methylation data.
Published Date
Mar 1, 2018
Journal
Volume
19
Issue
3
Pages
129 - 147
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