Presynaptic Regulation of Leptin in a Defined Lateral Hypothalamus–Ventral Tegmental Area Neurocircuitry Depends on Energy State
Abstract
Synaptic transmission controls brain activity and behaviors, including food intake. Leptin, an adipocyte-derived hormone, acts on neurons located in the lateral hypothalamic area (LHA) to maintain energy homeostasis and regulate food intake behavior. The specific synaptic mechanisms, cell types, and neural projections mediating this effect remain unclear. In male mice, using pathway-specific retrograde tracing, whole-cell patch-clamp recordings...
Paper Details
Title
Presynaptic Regulation of Leptin in a Defined Lateral Hypothalamus–Ventral Tegmental Area Neurocircuitry Depends on Energy State
Published Date
Oct 31, 2017
Journal
Volume
37
Issue
49
Pages
11854 - 11866
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