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Obesity: The myth of innocent obesity

Published on Dec 1, 2017in Nature Reviews Endocrinology24.646
· DOI :10.1038/nrendo.2017.146
Matthias Blüher79
Estimated H-index: 79
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Abstract
The concept of metabolically healthy obesity (MHO) suggests that obesity might be a benign condition. This view has been challenged by a recent study demonstrating that, among 3.5 million individuals, those with MHO still have a higher risk of cardiovascular diseases than individuals who are metabolically healthy and normal weight.
  • References (8)
  • Citations (4)
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References8
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#1Rishi Caleyachetty (University of Birmingham)H-Index: 8
#2G. Neil Thomas (University of Birmingham)H-Index: 37
Last. Krishnarajah Nirantharakumar (University of Birmingham)H-Index: 16
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Abstract Background Previous studies have been unclear about the cardiovascular risks for metabolically healthy obese individuals. Objectives This study examined the associations among metabolically healthy obese individuals and 4 different presentations of incident cardiovascular disease in a contemporary population. Methods We used linked electronic health records (1995 to 2015) in The Health Improvement Network (THIN) to assemble a cohort of 3.5 million individuals, 18 years of age or older a...
98 CitationsSource
#1Norbert StefanH-Index: 64
#2Hu HäringH-Index: 88
Last. Matthias B. SchulzeH-Index: 71
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Summary Obesity increases the risk of several other chronic diseases and, because of its epidemic proportions, has become a major public health problem worldwide. Alarmingly, a lower proportion of adults have tried to lose weight during the past decade than during the mid-1980s to 1990s. The first-line treatment option for obesity is lifestyle intervention. Although this approach can decrease fat mass in the short term, these beneficial effects typically do not persist. If a large amount of weig...
57 CitationsSource
#1Ashkan Afshin (UW: University of Washington)H-Index: 33
#2Mohammad H. Forouzanfar (UW: University of Washington)H-Index: 54
Last. Christopher MargonoH-Index: 162
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BACKGROUND Although the rising pandemic of obesity has received major attention in many countries, the effects of this attention on trends and the disease burden of obesity remain uncertain. METHOD ...
934 CitationsSource
#1Edward P. Weiss (WashU: Washington University in St. Louis)H-Index: 29
#2Stewart G. Albert (SLU: Saint Louis University)H-Index: 20
Last. Dennis T. Villareal (BCM: Baylor College of Medicine)H-Index: 46
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Weight loss from calorie restriction (CR) and/or endurance exercise training (EX) is cardioprotective. However CR and EX also have weight loss-independent benefits.We tested the hypothesis that weight loss from calorie restriction and exercise combined (CREX) improves cardiovascular disease (CVD) risk factors more so than similar weight loss from CR or EX alone.Overweight, sedentary men and women (n = 52; aged 45-65 y) were randomly assigned to undergo 6-8% weight loss by using CR, EX, or CREX. ...
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Obesity has become one of the major public health concerns of the past decades, because it is a key risk factor for type 2 diabetes, cardiovascular diseases, dyslipidemia, hypertension, and certain types of cancer, which may lead to increased mortality. Both treatment of obesity and prevention of obesity-related diseases are frequently not successful. Moreover, a subgroup of individuals with obesity does not seem to be at an increased risk for metabolic complications of obesity. In this literatu...
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#1Bjørn Mørkedal (NTNU: Norwegian University of Science and Technology)H-Index: 6
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Last. Imre Janszky (KI: Karolinska Institutet)H-Index: 36
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Objectives This study sought to investigate whether obesity in the absence of metabolic abnormalities might be a relatively benign condition in relation to acute myocardial infarction (AMI) and heart failure (HF). Background The results of previous studies are conflicting for AMI and largely unknown for HF, and the role of the duration of obesity has not been investigated. Methods In a population-based prospective cohort study, a total of 61,299 men and women free of cardiovascular disease were ...
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#2Marja-Liisa Nuotio (National Institute for Health and Welfare)H-Index: 11
Last. Bruce H. R. Wolffenbuttel (UMCG: University Medical Center Groningen)H-Index: 63
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Background Not all obese subjects have an adverse metabolic profile predisposing them to developing type 2 diabetes or cardiovascular disease. The BioSHaRE-EU Healthy Obese Project aims to gain insights into the consequences of (healthy) obesity using data on risk factors and phenotypes across several large-scale cohort studies. Aim of this study was to describe the prevalence of obesity, metabolic syndrome (MetS) and metabolically healthy obesity (MHO) in ten participating studies.
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Obesity contributes to reduced life expectancy, impaired quality of life and disabilities mainly in those individuals who develop cardiovascular diseases, type 2 diabetes, osteoarthritis and cancer. However, there is large variation in the individual risk to develop obesity-associated comorbid diseases which cannot simply be explained by the extent of adiposity. Observations that a proportion of individuals with obesity have a significantly lower risk for cardiometabolic abnormalities led to the...
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Obesity may not be consistently associated with metabolic disorders and mortality later in life, prompting exploration of the challenging concept of healthy obesity. Here, the consumption of a high-fat/high-sucrose (HF/HS) diet produces hyperglycaemia and hypercholesterolaemia, increases oxidative stress, increases endotoxaemia, expands adipose tissue (with enlarged adipocytes, enhanced macrophage infiltration and the accumulation of cholesterol and oxysterols), and reduces the median lifespan o...
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#1Rui Cao (UVA: University of Virginia)H-Index: 10
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Abstract Cerebral small vessel disease has been linked to cognitive, psychiatric and physical disabilities, especially in the elderly. However, the underlying pathophysiology remains incompletely understood, largely due to the limited accessibility of these small vessels in the live brain. Here, we report an intravital imaging and analysis platform for high-resolution, quantitative and comprehensive characterization of pathological alterations in the mouse cerebral microvasculature. By exploitin...
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#1João Sérgio Neves (University of Porto)H-Index: 8
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Background: Life expectancy of HIV-infected patients has increased with antiretroviral treatment (ART). Chronic diseases associated with ageing, including metabolic and cardiovascular diseases are becoming more prevalent in this population. We aimed to evaluate the association of obesity and ageing with cardiometabolic comorbidities and metabolic health status among patients with HIV infection. Methods: We evaluated 580 HIV-1 infected patients (71.7% male, mean age of 47.7±11.5 years). We analys...
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