A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity
Abstract
The 5-HT2CR agonist lorcaserin, clinically approved for the treatment of obesity, causes important side effects mainly related to subtype selectivity. In the search for 5-HT2CR allosteric modulators as safer antiobesity drugs, a chemical library from Vivia Biotech was screened using ExviTech platform. Structural modifications of identified hit VA240 in synthesized analogues 6–41 afforded compound 11...
Paper Details
Title
A Positive Allosteric Modulator of the Serotonin 5-HT2C Receptor for Obesity
Published Date
Nov 17, 2017
Volume
60
Issue
23
Pages
9575 - 9584
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