Weight cycling in adults with severe obesity: A longitudinal study

Published on Jul 1, 2018in Nutrition & Dietetics1.34
· DOI :10.1111/1747-0080.12387
Marwan El Ghoch15
Estimated H-index: 15
Simona Calugi23
Estimated H-index: 23
Riccardo Dalle Grave26
Estimated H-index: 26
Aim Although weight cycling is a common phenomenon in treatment-seeking patients with obesity, its consequences on health outcomes have not yet been completely clarified. We therefore aimed to investigate the effect of one cycle of intentional weight loss and regain on energy expenditure, body composition, cardiovascular risk factors and psychosocial variables in patients with severe obesity. Methods Clinical and psychosocial variables were measured in 38 adult patients with severe obesity (body mass index (BMI): 43.5 ± 7.2 kg/m2) consecutively readmitted to rehabilitative residential treatment (T1) for severe obesity after a cycle of weight loss (16.7 ±7.7 kg) and regain (15.1 ±11.3 kg), and compared with those recorded at a prior admission (T0). Results No significant differences were found between T0 and T1 values for weight, BMI, waist circumference, total body fat percentage, fat-free mass percentage, respiratory quotient, measured or predicted resting energy expenditure, metabolic adaptation, cardiovascular risk factors or psychosocial variables. However, younger patients (r = −0.38, P = 0.023) and those with higher historical weight (r = 0.43, P = 0.010) tended to regain more weight. Conclusions The absence of negative physical and psychological effects of weight cycling indicates that the risk of weight regain should not be a barrier to encouraging weight loss efforts in patients with severe obesity.
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Published on Mar 1, 2017in Obesity Research & Clinical Practice2.06
Grace Mackie1
Estimated H-index: 1
(USYD: University of Sydney),
Dorit Samocha-Bonet20
Estimated H-index: 20
(UNSW: University of New South Wales),
Charmaine S. Tam19
Estimated H-index: 19
(USYD: University of Sydney)
Summary Background There remains common belief in the general community that weight cycling or ‘yo-yo dieting’ is associated with potential adverse effects on obesity and metabolic risk factors. In 1994, a review by the National Task Force on the Prevention and Treatment of Obesity concluded that weight cycling did not impact metabolism, and that weight loss attempts should not be discouraged. This study is an updated review of the literature published since 1994, to determine if weight cycling ...
Published on Dec 1, 2016in Current obesity reports
Michael Müller94
Estimated H-index: 94
(CAU: University of Kiel),
Janna Enderle7
Estimated H-index: 7
(CAU: University of Kiel),
Anja Bosy-Westphal40
Estimated H-index: 40
(University of Hohenheim)
Metabolic adaptation to weight changes relates to body weight control, obesity and malnutrition. Adaptive thermogenesis (AT) refers to changes in resting and non-resting energy expenditure (REE and nREE) which are independent from changes in fat-free mass (FFM) and FFM composition. AT differs in response to changes in energy balance. With negative energy balance, AT is directed towards energy sparing. It relates to a reset of biological defence of body weight and mainly refers to REE. After weig...
Published on Aug 1, 2016in Obesity3.97
Erin Fothergill2
Estimated H-index: 2
(NIH: National Institutes of Health),
Juen Guo11
Estimated H-index: 11
(NIH: National Institutes of Health)
+ 8 AuthorsPeter Walter103
Estimated H-index: 103
(NIH: National Institutes of Health)
Objective To measure long-term changes in resting metabolic rate (RMR) and body composition in participants of “The Biggest Loser” competition. Methods Body composition was measured by dual energy X-ray absorptiometry, and RMR was determined by indirect calorimetry at baseline, at the end of the 30-week competition and 6 years later. Metabolic adaptation was defined as the residual RMR after adjusting for changes in body composition and age. Results Of the 16 “Biggest Loser” competitors original...
Published on Jul 1, 2016in International Journal of Eating Disorders3.52
Simona Calugi23
Estimated H-index: 23
Antonella Ruocco5
Estimated H-index: 5
+ 4 AuthorsRiccardo Dalle Grave26
Estimated H-index: 26
Objective The aim of this prospective case–control study was to compare the long-term effects of a residential cognitive-behavioral treatment (CBT) for weight loss in severely obese patients with and without binge-eating disorder (BED). Methods We assessed weight-loss outcomes and psychological impairment in 54 severely obese female patients with BED and 54 patients matched by age, gender, and body mass index (BMI) without BED admitted to a residential CBT program. Body weight was measured at ba...
Published on Apr 1, 2016in Cell Metabolism22.41
Faidon Magkos43
Estimated H-index: 43
(Agency for Science, Technology and Research),
Gemma Fraterrigo5
Estimated H-index: 5
(WashU: Washington University in St. Louis)
+ 8 AuthorsBruce W. Patterson52
Estimated H-index: 52
(WashU: Washington University in St. Louis)
Although 5%–10% weight loss is routinely recommended for people with obesity, the precise effects of 5% and further weight loss on metabolic health are unclear. We conducted a randomized controlled trial that evaluated the effects of 5.1% ± 0.9% (n = 19), 10.8% ± 1.3% (n = 9), and 16.4% ± 2.1% (n = 9) weight loss and weight maintenance (n = 14) on metabolic outcomes. 5% weight loss improved adipose tissue, liver and muscle insulin sensitivity, and b cell function, without a concomitant change in...
Published on Feb 1, 2016in Clinical Nutrition6.40
David C. Frankenfield26
Estimated H-index: 26
(Penn State Milton S. Hershey Medical Center),
Christine M. Ashcraft5
Estimated H-index: 5
(Penn State Milton S. Hershey Medical Center)
+ 1 AuthorsVernon M. Chinchilli63
Estimated H-index: 63
(PSU: Pennsylvania State University)
Summary Background Validation data for currently available indirect calorimeters is limited. The purpose of this investigation was to validate a newer indirect calorimeter system (Vmax Encore) against a criterion device (Deltatrac Metabolic Monitor) in spontaneously breathing mode. Materials and methods An n-of-1 methodology was used in which both indirect calorimeters were employed in the same subject repeatedly until 15 measurement pairs were generated for oxygen consumption (VO 2 ), carbon di...
Published on Oct 1, 2015in The American Journal of Clinical Nutrition6.57
Manfred James Müller35
Estimated H-index: 35
Janna Enderle7
Estimated H-index: 7
+ 7 AuthorsAnja Bosy-Westphal40
Estimated H-index: 40
(University of Hohenheim)
Adaptive thermogenesis (AT) is the fat-free mass (FFM)-independent reduction of resting energy expenditure (REE) to caloric restriction (CR). AT attenuates weight loss and favors weight regain. Its variance, dynamics, and control remain obscure.Our aims were to address the variance and kinetics of AT, its associations with body composition in the context of endocrine determinants, and its effect on weight regain.Thirty-two nonobese men underwent sequential overfeeding (1 wk at +50% of energy nee...
Published on Jan 1, 2015in Obesity Facts2.65
Volkan Yumuk15
Estimated H-index: 15
Constantine Tsigos30
Estimated H-index: 30
+ 4 AuthorsHermann Toplak24
Estimated H-index: 24
Obesity is a chronic metabolic disease characterised by an increase of body fat stores. It is a gateway to ill health, and it has become one of the leading causes of disability and death, affecting no
Published on Oct 1, 2014in Diabetes Care15.27
Linda M. Delahanty37
Estimated H-index: 37
(Harvard University),
Qing Pan13
Estimated H-index: 13
(GW: George Washington University)
+ 7 AuthorsPaul W. Franks81
Estimated H-index: 81
(Harvard University)
OBJECTIVE This study examined specific measures of weight loss in relation to incident diabetes and improvement in cardiometabolic risk factors. RESEARCH DESIGN AND METHODS This prospective, observational study analyzed nine weight measures, characterizing baseline weight, short- versus long-term weight loss, short- versus long-term weight regain, and weight cycling, within the Diabetes Prevention Program (DPP) lifestyle intervention arm ( n = 1,000) for predictors of incident diabetes and impro...
Published on Jan 1, 2014in Journal of Obesity
Cynthia M. Kroeger12
Estimated H-index: 12
(UIC: University of Illinois at Chicago),
Kristin K. Hoddy8
Estimated H-index: 8
(UIC: University of Illinois at Chicago),
Krista A. Varady21
Estimated H-index: 21
Dietary restriction interventions are effective for weight loss and reduction of chronic disease risk. Unfortunately, most people tend to regain much of this lost weight within one year after intervention. While some studies suggest that minor degrees of weight regain have no effect on metabolic disease risk parameters, other studies demonstrate a complete reversal in metabolic benefits. In light of these conflicting findings, it is of interest to determine how complete weight maintenance versus...
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