Location of Mutation in BRCA2 Gene and Survival in Patients with Ovarian Cancer
Abstract
Purpose: BRCA2 plays a central role in homologous recombination by loading RAD51 on DNA breaks. The objective of this study is to determine whether the location of mutations in the RAD51-binding domain (RAD51-BD; exon 11) of BRCA2 gene affects the clinical outcome of ovarian cancer patients.Experimental Design: A study cohort of 353 women with ovarian cancer who underwent genetic germline testing for BRCA1 and BRCA2 genes was identified....
Paper Details
Title
Location of Mutation in BRCA2 Gene and Survival in Patients with Ovarian Cancer
Published Date
Jan 15, 2018
Journal
Volume
24
Issue
2
Pages
326 - 333
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