Neural and Molecular Mechanisms Involved in Controlling the Quality of Feeding Behavior: Diet Selection and Feeding Patterns

Published on Oct 20, 2017in Nutrients 4.20
· DOI :10.3390/nu9101151
Tsutomu Sasaki27
Estimated H-index: 27
Abstract
We are what we eat. There are three aspects of feeding: what, when, and how much. These aspects represent the quantity (how much) and quality (what and when) of feeding. The quantitative aspect of feeding has been studied extensively, because weight is primarily determined by the balance between caloric intake and expenditure. In contrast, less is known about the mechanisms that regulate the qualitative aspects of feeding, although they also significantly impact the control of weight and health. However, two aspects of feeding quality relevant to weight loss and weight regain are discussed in this review: macronutrient-based diet selection (what) and feeding pattern (when). This review covers the importance of these two factors in controlling weight and health, and the central mechanisms that regulate them. The relatively limited and fragmented knowledge on these topics indicates that we lack an integrated understanding of the qualitative aspects of feeding behavior. To promote better understanding of weight control, research efforts must focus more on the mechanisms that control the quality and quantity of feeding behavior. This understanding will contribute to improving dietary interventions for achieving weight control and for preventing weight regain following weight loss.
  • References (339)
  • Citations (5)
Cite
References339
Published on Sep 1, 2015in Peptides 2.85
Hiroharu Mifune12
Estimated H-index: 12
(Kurume University),
Yuji Tajiri10
Estimated H-index: 10
(Kurume University)
+ 6 AuthorsMasayasu Kojima77
Estimated H-index: 77
(Kurume University)
Abstract In the present study, effects of voluntary exercise in an obese animal model were investigated in relation to the rhythm of daily activity and ghrelin production. Male Sprague–Dawley rats were fed either a high fat diet (HFD) or a chow diet (CD) from four to 16 weeks old. They were further subdivided into either an exercise group (HFD-Ex, CD-Ex) with a running wheel for three days of every other week or sedentary group (HFD-Se, CD-Se). At 16 weeks old, marked increases in body weight an...
10 Citations Source Cite
Published on Dec 1, 2015in Molecular and Cellular Endocrinology 3.56
Neeta Khandekar2
Estimated H-index: 2
(Garvan Institute of Medical Research),
Britt A. Berning2
Estimated H-index: 2
(Garvan Institute of Medical Research)
+ 1 AuthorsShu Lin28
Estimated H-index: 28
(University of New South Wales)
Abstract Imbalances in normal regulation of food intake can cause obesity and related disorders. Inadequate therapies for such disorders necessitate better understanding of mechanisms that regulate energy homeostasis. Pancreatic polypeptide (PP), a robust anorexigenic hormone, effectively modulates food intake and energy homeostasis, thus potentially aiding anti-obesity therapeutics. Intra-gastric and intra-intestinal infusion of nutrients stimulate PP secretion from the gastrointestinal tract, ...
13 Citations Source Cite
Published on Jan 1, 1992in Progress in Brain Research 3.17
Andries Kalsbeek58
Estimated H-index: 58
(Centre national de la recherche scientifique),
Ruud M. Buijs54
Estimated H-index: 54
Publisher Summary This chapter describes peptidergic transmitters of the suprachiasmatic nuclei and the control of circadian rhythmicity and the plasma corticosterone rhythm, because corticotropin-releasing factor (CRF) neurons, regulating the release of adrenocorticotropin hormone (ACTH) and corticosterone, are located in the paraventricular nucleus (PVN). The close relationship between the changes in plasma ACTH and corticosterone levels indicates that the inhibitory effect of vasopressin (VP)...
48 Citations Source Cite
Published on May 1, 2008in Sleep 5.13
Zhiwei Guan7
Estimated H-index: 7
(Pennsylvania State University),
Alexandros N. Vgontzas61
Estimated H-index: 61
(Pennsylvania State University)
+ 1 AuthorsJidong Fang40
Estimated H-index: 40
(Pennsylvania State University)
OBESITY IS A MAJOR HEALTH PROBLEM FOUND IN MODERN SOCIETIES AND IS STILL INCREASING IN MANY COUNTRIES. ABOUT 60% OF ADULTS ARE overweight or obese in the United States.1 Numerous studies indicate that obesity is closely associated with sleep disturbances, which are also a major health problem. Excessive daytime sleepiness (EDS) is one of the most common complaints of obese patients, and is also the most frequent complaint in a sleep clinic. Obesity is often associated with sleep disordered breat...
35 Citations Source Cite
Published on Jul 1, 2001in Nature Neuroscience 19.91
Gary Aston-Jones74
Estimated H-index: 74
(University of Pennsylvania),
Sheng Chen3
Estimated H-index: 3
(University of Pennsylvania)
+ 1 AuthorsMichael L. Oshinsky17
Estimated H-index: 17
(University of Pennsylvania)
449 Citations Source Cite
Published on Jul 1, 2009in Annals of the New York Academy of Sciences 4.28
Valerie B. Duffy35
Estimated H-index: 35
(University of Connecticut),
John E. Hayes25
Estimated H-index: 25
(Brown University)
+ 1 AuthorsPouran D. Faghri16
Estimated H-index: 16
(University of Connecticut)
Genetics, environmental exposures, and aging interact to produce variations in the perception or liking of taste, olfaction, and somatosensory sensations (i.e., chemosensation). Chemosensory variation can affect disease risk by influencing what people like and choose to eat from abundant supplies of desirable high-fat, sweet, and salty foods and alcoholic beverages at the expense of less-available or less-liked vegetables. We contend that assessing dietary preference via liking‐disliking surveys...
88 Citations Source Cite
Published on Sep 1, 2015in Cell Metabolism 20.57
Nicole Michelle Kettner6
Estimated H-index: 6
(Baylor College of Medicine),
Sara A. Mayo1
Estimated H-index: 1
(Baylor College of Medicine)
+ 3 AuthorsLoning Fu13
Estimated H-index: 13
(Baylor College of Medicine)
Summary Circadian disruption is associated with obesity, implicating the central clock in body weight control. Our comprehensive screen of wild-type and three circadian mutant mouse models, with or without chronic jet lag, shows that distinct genetic and physiologic interventions differentially disrupt overall energy homeostasis and Leptin signaling. We found that BMAL1/CLOCK generates circadian rhythm of C/EBPα-mediated leptin transcription in adipose. Per and Cry mutant mice show similar disru...
60 Citations Source Cite
Published on Jan 1, 2012in Addiction Biology 5.58
Karolina P. Skibicka28
Estimated H-index: 28
(University of Gothenburg),
Caroline Hansson15
Estimated H-index: 15
(University of Gothenburg)
+ 1 AuthorsSuzanne L. Dickson45
Estimated H-index: 45
(University of Gothenburg)
The decision to eat is strongly influenced by non-homeostatic factors such as food palatability. Indeed, the rewarding and motivational value of food can override homeostatic signals, leading to increased consumption and hence, obesity. Ghrelin, a gut-derived orexigenic hormone, has a prominent role in homeostatic feeding. Recently, however, it has emerged as a potent modulator of the mesolimbic dopaminergic reward pathway, suggesting a role for ghrelin in food reward. Here, we sought to determi...
138 Citations Source Cite
Published on Sep 1, 2015in Trends in Endocrinology and Metabolism 10.77
Laura Steinbusch2
Estimated H-index: 2
(University of Lausanne),
Gwenaël Labouèbe11
Estimated H-index: 11
(University of Lausanne),
Bernard Thorens71
Estimated H-index: 71
(University of Lausanne)
Glucose homeostasis as well as homeostatic and hedonic control of feeding is regulated by hormonal, neuronal, and nutrient-related cues. Glucose, besides its role as a source of metabolic energy, is an important signal controlling hormone secretion and neuronal activity, hence contributing to whole-body metabolic integration in coordination with feeding control. Brain glucose sensing plays a key, but insufficiently explored, role in these metabolic and behavioral controls, which when deregulated...
31 Citations Source Cite
Published on Dec 15, 2008in The Journal of Physiology
Jorge E. Mendoza20
Estimated H-index: 20
(Centre national de la recherche scientifique),
Paul Pévet59
Estimated H-index: 59
(Centre national de la recherche scientifique),
Etienne Challet39
Estimated H-index: 39
(Centre national de la recherche scientifique)
High-fat feeding in rodents leads to metabolic abnormalities mimicking the human metabolic syndrome, including obesity and insulin resistance. These metabolic diseases are associated with altered temporal organization of many physiological functions. The master circadian clock located in the suprachiasmatic nuclei controls most physiological functions and metabolic processes. Furthermore, under certain conditions of feeding (hypocaloric diet), metabolic cues are capable of altering the suprachia...
128 Citations Source Cite
  • References (339)
  • Citations (5)
Cite
Cited By5
Published on Dec 1, 2018in Molecular Brain 3.45
Tsutomu Sasaki27
Estimated H-index: 27
(Gunma University),
Rika Numano8
Estimated H-index: 8
(Toyohashi University of Technology)
+ 4 AuthorsTadahiro Kitamura32
Estimated H-index: 32
(Gunma University)
A high-fat diet (HFD) causes obesity by promoting excessive energy intake, and simultaneously, by disturbing the timing of energy intake. Restoring the feeding pattern is sufficient to prevent HFD-induced obesity in mice. However, the molecular mechanism(s) underlying HFD-induced feeding pattern disturbances remain elusive. Saturated fatty acids activate microglia and cause hypothalamic inflammation. Activated microglia cause neuroinflammation, which spreads via inflammatory cytokines and gap-ju...
1 Citations Source Cite
Published on Dec 1, 2018in Pharmacology, Biochemistry and Behavior 2.54
Marcel Pérez-Morales (Universidad Autónoma Metropolitana), Gabriela Hurtado-Alvarado8
Estimated H-index: 8
(Universidad Autónoma Metropolitana)
+ 3 AuthorsJavier Velázquez-Moctezuma21
Estimated H-index: 21
(Universidad Autónoma Metropolitana)
Abstract One of the approaches to induce obesity in rodents consists in reducing litter size to 3 pups during the lactation period. Animals submitted to this manipulation are heavier, hyperphagic and develop several metabolic diseases for the rest of their lives. In the present study, under the premise that melanin-concentrating hormone (MCH), an orexigenic peptide synthesized by neurons of the lateral hypothalamus, is involved in food intake regulation, we aimed to measure the hypothalamic expr...
Source Cite
Published on Dec 1, 2018in Nature Communications 12.35
Sho Matsui4
Estimated H-index: 4
(Gunma University),
Tsutomu Sasaki27
Estimated H-index: 27
(Gunma University)
+ 11 AuthorsAkihiro Yamanaka37
Estimated H-index: 37
(Nagoya University)
Diet affects health through ingested calories and macronutrients, and macronutrient balance affects health span. The mechanisms regulating macronutrient-based diet choices are poorly understood. Previous studies had shown that NAD-dependent deacetylase sirtuin-1 (SIRT1) in part influences the health-promoting effects of caloric restriction by boosting fat use in peripheral tissues. Here, we show that neuronal SIRT1 shifts diet choice from sucrose to fat in mice, matching the peripheral metabolic...
1 Citations Source Cite
Published on Nov 26, 2018in Frontiers in Physiology 3.39
Roger Mariné-Casadó2
Estimated H-index: 2
,
Cristina Domenech-Coca1
Estimated H-index: 1
+ 3 AuthorsAntoni Caimari16
Estimated H-index: 16
We previously demonstrated that chronic exposure to different photoperiods induced marked variations in several glucose and lipid metabolism-related parameters in normoweight Fischer 344 (F344) rats. Here, we examined the effects of the combination of an obesogenic cafeteria diet (CAF) and the chronic exposure to three different day lengths (L12, 12 h light/day; L18, 18 h light/day and L6, 6 h light/day) in this rat strain. Although no changes were observed during the first 4 weeks of adaptation...
Source Cite
Published on Apr 1, 2019in Biochimica et Biophysica Acta 3.44
Deborah Amos2
Estimated H-index: 2
(Marshall University),
Carla Cook8
Estimated H-index: 8
(Marshall University),
Nalini Santanam31
Estimated H-index: 31
(Marshall University)
Abstract With obesity rates reaching epidemic proportions, more studies concentrated on reducing the risk and treating this epidemic are vital. Redox stress is an important metabolic regulator involved in the pathophysiology of cardiovascular disease, Type 2 diabetes, and obesity. Oxygen and nitrogen-derived free radicals alter glucose and lipid homeostasis in key metabolic tissues, leading to increases in risk of developing metabolic syndrome. Oxidants derived from dietary fat differ in their m...
Source Cite