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Neural and Molecular Mechanisms Involved in Controlling the Quality of Feeding Behavior: Diet Selection and Feeding Patterns

Published on Oct 20, 2017in Nutrients 4.20
· DOI :10.3390/nu9101151
Tsutomu Sasaki27
Estimated H-index: 27
Abstract
We are what we eat. There are three aspects of feeding: what, when, and how much. These aspects represent the quantity (how much) and quality (what and when) of feeding. The quantitative aspect of feeding has been studied extensively, because weight is primarily determined by the balance between caloric intake and expenditure. In contrast, less is known about the mechanisms that regulate the qualitative aspects of feeding, although they also significantly impact the control of weight and health. However, two aspects of feeding quality relevant to weight loss and weight regain are discussed in this review: macronutrient-based diet selection (what) and feeding pattern (when). This review covers the importance of these two factors in controlling weight and health, and the central mechanisms that regulate them. The relatively limited and fragmented knowledge on these topics indicates that we lack an integrated understanding of the qualitative aspects of feeding behavior. To promote better understanding of weight control, research efforts must focus more on the mechanisms that control the quality and quantity of feeding behavior. This understanding will contribute to improving dietary interventions for achieving weight control and for preventing weight regain following weight loss.
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  • Citations (5)
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References339
Newest
Published on Dec 1, 2017in Scientific Reports 4.12
Agatha A. van der Klaauw15
Estimated H-index: 15
(University of Cambridge),
Hisham Ziauddeen16
Estimated H-index: 16
(University of Cambridge)
+ 4 AuthorsI. Sadaf Farooqi71
Estimated H-index: 71
(University of Cambridge)
The aim of this study was to use functional neuroimaging to investigate whether oxytocin modulates the neural response to visual food cues in brain regions involved in the control of food intake. Twenty-four normal weight volunteers received intranasal oxytocin (24 IU) or placebo in a double-blind, randomized crossover study. Measurements were made forty-five minutes after dosing. On two occasions, functional MRI (fMRI) scans were performed in the fasted state; the blood oxygen level-dependent (...
9 Citations Source Cite
Published on Nov 1, 2017in The Lancet 53.25
Mahshid Dehghan22
Estimated H-index: 22
(Population Health Research Institute),
Andrew Mente30
Estimated H-index: 30
(McMaster University)
+ 352 AuthorsAnders H. Rosengren84
Estimated H-index: 84
(University of Gothenburg)
Summary Background The relationship between macronutrients and cardiovascular disease and mortality is controversial. Most available data are from European and North American populations where nutrition excess is more likely, so their applicability to other populations is unclear. Methods The Prospective Urban Rural Epidemiology (PURE) study is a large, epidemiological cohort study of individuals aged 35–70 years (enrolled between Jan 1, 2003, and March 31, 2013) in 18 countries with a median fo...
168 Citations Source Cite
Published on Aug 3, 2017in JCI insight
Joe J. Simon13
Estimated H-index: 13
,
Anne Wetzel1
Estimated H-index: 1
+ 6 AuthorsHans-Christoph Friederich33
Estimated H-index: 33
13 Citations Source Cite
Published on Jul 27, 2017in Nature Communications 12.35
Aaron F. McDaid11
Estimated H-index: 11
,
Peter K. Joshi21
Estimated H-index: 21
+ 16 AuthorsAlexandre Reymond11
Estimated H-index: 11
(University of Lausanne)
Along with various environmental factors, a complex genetic architecture influences human lifespan. Here, McDaid and colleagues reveal novel loci associated with human lifespan and linked biomarkers by Bayesian association scan.
10 Citations Source Cite
Published on Aug 1, 2017in Neuron 14.32
Mark L. Andermann24
Estimated H-index: 24
(Harvard University),
Bradford B. Lowell85
Estimated H-index: 85
(Harvard University)
Prior mouse genetic research has set the stage for a deep understanding of appetite regulation. This goal is now being realized through the use of recent technological advances, such as the ability to map connectivity between neurons, manipulate neural activity in real time, and measure neural activity during behavior. Indeed, major progress has been made with regard to meal-related gut control of appetite, arcuate nucleus-based hypothalamic circuits linking energy state to the motivational driv...
57 Citations Source Cite
Published on Aug 1, 2017in European Journal of Nutrition 4.42
Danila Del Rio4
Estimated H-index: 4
,
Paula Stucchi2
Estimated H-index: 2
(Rio de Janeiro State University)
+ 5 AuthorsMariano Ruiz-Gayo24
Estimated H-index: 24
Purpose Our aim was to characterize the effect of an unfamiliar high-fat diet (HFD) on circadian feeding behaviour, plasma parameters, body weight (BW), and gene expression in the prefrontal cortex (PFC) of adolescent male mice. To this end, mice were allowed to consume a HFD during 48 h, but one group was allowed a free choice of HFD or normal chow (FC-HFD), while the other was restricted to a non-optional unfamiliar HFD feeding (NOP-HFD).
3 Citations Source Cite
Published on Jul 1, 2017in Nature Medicine 32.62
Ruixin Liu13
Estimated H-index: 13
(Shanghai Jiao Tong University),
Jie Hong30
Estimated H-index: 30
(Shanghai Jiao Tong University)
+ 45 AuthorsXiaokai Wang6
Estimated H-index: 6
(Chinese Academy of Sciences)
Composition of gut bacteria and serum metabolites in young, obese individuals is partially restored following weight loss surgery, including Bacteroides thetaiotaomicron, which decreases serum glutamate levels and fat mass gain in mice.
125 Citations Source Cite
Published on Jul 1, 2017in Cell Metabolism 20.57
Martin Valdearcos11
Estimated H-index: 11
(University of California, San Francisco),
John D. Douglass4
Estimated H-index: 4
(University of Washington)
+ 8 AuthorsJoshua P. Thaler25
Estimated H-index: 25
(University of Washington)
Summary Dietary excess triggers accumulation of pro-inflammatory microglia in the mediobasal hypothalamus (MBH), but the components of this microgliosis and its metabolic consequences remain uncertain. Here, we show that microglial inflammatory signaling determines the immunologic response of the MBH to dietary excess and regulates hypothalamic control of energy homeostasis in mice. Either pharmacologically depleting microglia or selectively restraining microglial NF-κB-dependent signaling sharp...
68 Citations Source Cite
Published on May 5, 2017in Science 41.06
Qili Liu7
Estimated H-index: 7
(Johns Hopkins University),
Masashi Tabuchi4
Estimated H-index: 4
(Johns Hopkins University)
+ 6 AuthorsMark N. Wu20
Estimated H-index: 20
(Johns Hopkins University)
Free-living animals must not only regulate the amount of food they consume but also choose which types of food to ingest. The shifting of food preference driven by nutrient-specific hunger can be essential for survival, yet little is known about the underlying mechanisms. We identified a dopamine circuit that encodes protein-specific hunger in Drosophila . The activity of these neurons increased after substantial protein deprivation. Activation of this circuit simultaneously promoted protein int...
22 Citations Source Cite
Published on May 1, 2017in Gastroenterology 20.77
Kevin D. Hall37
Estimated H-index: 37
(National Institutes of Health),
Juen Guo11
Estimated H-index: 11
(National Institutes of Health)
Weight changes are accompanied by imbalances between calorie intake and expenditure. This fact is often misinterpreted to suggest that obesity is caused by gluttony and sloth and can be treated by simply advising people to eat less and move more. Rather various components of energy balance are dynamically interrelated and weight loss is resisted by counterbalancing physiological processes. While low-carbohydrate diets have been suggested to partially subvert these processes by increasing energy ...
39 Citations Source Cite
Cited By5
Newest
Published on Apr 1, 2019in Biochimica et Biophysica Acta 3.44
Deborah Amos2
Estimated H-index: 2
(Marshall University),
Carla Cook8
Estimated H-index: 8
(Marshall University),
Nalini Santanam31
Estimated H-index: 31
(Marshall University)
Abstract With obesity rates reaching epidemic proportions, more studies concentrated on reducing the risk and treating this epidemic are vital. Redox stress is an important metabolic regulator involved in the pathophysiology of cardiovascular disease, Type 2 diabetes, and obesity. Oxygen and nitrogen-derived free radicals alter glucose and lipid homeostasis in key metabolic tissues, leading to increases in risk of developing metabolic syndrome. Oxidants derived from dietary fat differ in their m...
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Published on Dec 1, 2018in Nature Communications 12.35
Sho Matsui4
Estimated H-index: 4
(Gunma University),
Tsutomu Sasaki27
Estimated H-index: 27
(Gunma University)
+ 11 AuthorsAkihiro Yamanaka38
Estimated H-index: 38
(Nagoya University)
Diet affects health through ingested calories and macronutrients, and macronutrient balance affects health span. The mechanisms regulating macronutrient-based diet choices are poorly understood. Previous studies had shown that NAD-dependent deacetylase sirtuin-1 (SIRT1) in part influences the health-promoting effects of caloric restriction by boosting fat use in peripheral tissues. Here, we show that neuronal SIRT1 shifts diet choice from sucrose to fat in mice, matching the peripheral metabolic...
2 Citations Source Cite
Published on Dec 1, 2018in Pharmacology, Biochemistry and Behavior 2.54
Marcel Pérez-Morales (Universidad Autónoma Metropolitana), Gabriela Hurtado-Alvarado8
Estimated H-index: 8
(Universidad Autónoma Metropolitana)
+ 3 AuthorsJavier Velázquez-Moctezuma21
Estimated H-index: 21
(Universidad Autónoma Metropolitana)
Abstract One of the approaches to induce obesity in rodents consists in reducing litter size to 3 pups during the lactation period. Animals submitted to this manipulation are heavier, hyperphagic and develop several metabolic diseases for the rest of their lives. In the present study, under the premise that melanin-concentrating hormone (MCH), an orexigenic peptide synthesized by neurons of the lateral hypothalamus, is involved in food intake regulation, we aimed to measure the hypothalamic expr...
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Published on Dec 1, 2018in Molecular Brain 3.45
Tsutomu Sasaki27
Estimated H-index: 27
(Gunma University),
Rika Numano14
Estimated H-index: 14
(Toyohashi University of Technology)
+ 4 AuthorsTadahiro Kitamura33
Estimated H-index: 33
(Gunma University)
A high-fat diet (HFD) causes obesity by promoting excessive energy intake, and simultaneously, by disturbing the timing of energy intake. Restoring the feeding pattern is sufficient to prevent HFD-induced obesity in mice. However, the molecular mechanism(s) underlying HFD-induced feeding pattern disturbances remain elusive. Saturated fatty acids activate microglia and cause hypothalamic inflammation. Activated microglia cause neuroinflammation, which spreads via inflammatory cytokines and gap-ju...
2 Citations Source Cite
Published on Nov 26, 2018in Frontiers in Physiology 3.39
Roger Mariné-Casadó2
Estimated H-index: 2
,
Cristina Domenech-Coca1
Estimated H-index: 1
+ 3 AuthorsAntoni Caimari16
Estimated H-index: 16
We previously demonstrated that chronic exposure to different photoperiods induced marked variations in several glucose and lipid metabolism-related parameters in normoweight Fischer 344 (F344) rats. Here, we examined the effects of the combination of an obesogenic cafeteria diet (CAF) and the chronic exposure to three different day lengths (L12, 12 h light/day; L18, 18 h light/day and L6, 6 h light/day) in this rat strain. Although no changes were observed during the first 4 weeks of adaptation...
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