Composite biomarkers improve classification of drug-induced channel block

The Micro-Electrode Array device enables high-throughput electrophysiology measurements that are less labour-intensive than patch-clamp based techniques. Combined with human-induced pluripotent stem cells cardiomyocytes (hiPSC-CM), it represents a new and promising paradigm for automated and accurate in vitro drug safety evaluation. In this article, the following question is addressed: which features of the MEA signals should be measured to...