Antiapoptotic serine protease inhibitors contribute to survival of allergenic T H 2 cells

The mechanisms that regulate maintenance of persistent TH2 cells and potentiate allergic inflammation are not well understood.The function of serine protease inhibitor 2A (Spi2A) was studied in mouse TH2 cells, and the serine protease inhibitor B3 (SERPINB3) and SERPINB4 genes were studied in TH2 cells from patients with grass pollen allergy.Spi2A-deficient TH2 cells were studied in in vitro culture or in vivo after challenge of Spi2A knockout...