The Unfolded Protein Response and Cell Fate Control
Abstract
The secretory capacity of a cell is constantly challenged by physiological demands and pathological perturbations. To adjust and match the protein-folding capacity of the endoplasmic reticulum (ER) to changing secretory needs, cells employ a dynamic intracellular signaling pathway known as the unfolded protein response (UPR). Homeostatic activation of the UPR enforces adaptive programs that modulate and augment key aspects of the entire...
Paper Details
Title
The Unfolded Protein Response and Cell Fate Control
Published Date
Jan 18, 2018
Journal
Volume
69
Issue
2
Pages
169 - 181
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Notes
History