Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
Abstract
Cysteine hydropersulfide (CysSSH) occurs in abundant quantities in various organisms, yet little is known about its biosynthesis and physiological functions. Extensive persulfide formation is apparent in cysteine-containing proteins in Escherichia coli and mammalian cells and is believed to result from post-translational processes involving hydrogen sulfide-related chemistry. Here we demonstrate effective CysSSH synthesis from the substrate l...
Paper Details
Title
Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics
Published Date
Oct 27, 2017
Journal
Volume
8
Issue
1
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