ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome‐ and lysozyme‐dependent degradation

Volume: 119, Issue: 4, Pages: 3030 - 3043
Published: Dec 26, 2017
Abstract
ABIN1, an important immune regulator, has been shown to be involved in various cellular functions, such as immunity, development, tissue homeostasis, and tumor progression. It inhibits TNF- and TLR-induced NF-κB signaling activation and the consequent gene expression. Despite its functional significance, the mechanism of ABIN1 in the regulation of various cellular functions remains unclear. In this study, we identified HDAC1, a key regulator of...
Paper Details
Title
ABIN1 inhibits HDAC1 ubiquitination and protects it from both proteasome‐ and lysozyme‐dependent degradation
Published Date
Dec 26, 2017
Volume
119
Issue
4
Pages
3030 - 3043
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