SPSB3 targets SNAIL for degradation in GSK-3β phosphorylation-dependent manner and regulates metastasis
Abstract
Epithelial-mesenchymal transition (EMT) is a process during which normal epithelial cells acquire mesenchymal characteristics. EMT has a critical role in various human diseases especially in cancer. EMT facilitates tumor initiation and progression by mediating cancer cell stemness and motility. Zinc finger transcription factor SNAIL is one of the most important initiators of EMT. Therefore, it is of great significance to understand the...
Paper Details
Title
SPSB3 targets SNAIL for degradation in GSK-3β phosphorylation-dependent manner and regulates metastasis
Published Date
Oct 23, 2017
Journal
Volume
37
Issue
6
Pages
768 - 776
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